Michigan State University, originally established as the Michigan Agricultural College in 1855, was officially designated as a land-grant institution under the Morrill Act in 1863, predating the formal designation of some other universities. Other universities with a similar claim:
Iowa State University – Chartered in 1858, designated as a land-grant institution in 1864.
University of Illinois at Urbana-Champaign – Chartered in 1867, designated as a land-grant institution in 1867.
University of California, Berkeley – Chartered in 1868, designated as a land-grant institution in 1868.
Kansas State University – Chartered in 1863 as Kansas State Agricultural College, designated as a land-grant institution in 1863.
University of Wisconsin-Madison – Chartered in 1848, designated as a land-grant institution in 1866.
Association of Public Land-Grant Universities